NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Securityvs21 CFR Part 58 - Good Laboratory Practice (GLP)
See exactly how NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security controls map to 21 CFR Part 58 - Good Laboratory Practice (GLP). Pre-computed mappings, identified gaps, and coverage analysis.
According to the TheArtOfService Compliance Knowledge Graph:
NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security maps to 21 CFR Part 58 - Good Laboratory Practice (GLP) with 38% coverage across 3 directly mapped controls. Analysis of 8 NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security controls identifies 5 compliance gaps — primarily concentrated in OT Supply Chain, Lifecycle, Physical.
Source: TheArtOfService Knowledge Graph | 8 controls analysed | 718 frameworks | 330K+ cross-framework mappings
Control Mappings
Showing 6 of 6 mapped controls across 3 domains. Sign up to explore all 330K+ mappings across 718 frameworks.
OT Security Program Governance(2 mappings)
OT Access Control and IAM(2 mappings)
OT Incident Response and Recovery(2 mappings)
Related Comparisons
Other NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security comparisons
Other 21 CFR Part 58 - Good Laboratory Practice (GLP) comparisons
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What are the key differences between NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security and 21 CFR Part 58 - Good Laboratory Practice (GLP)?
NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security has 8 controls across its framework, while 21 CFR Part 58 - Good Laboratory Practice (GLP) covers 31 controls. Direct mapping analysis identifies 3 overlapping controls (38% coverage). The frameworks diverge most significantly in OT Supply Chain, Lifecycle, Physical, where 1 NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security controls have no direct 21 CFR Part 58 - Good Laboratory Practice (GLP) equivalent.
How many controls map between NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security and 21 CFR Part 58 - Good Laboratory Practice (GLP)?
Of 8 total NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security controls, 3 map directly to 21 CFR Part 58 - Good Laboratory Practice (GLP) controls — representing 38% coverage. The remaining 5 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.
What are the compliance gaps when mapping NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security to 21 CFR Part 58 - Good Laboratory Practice (GLP)?
5 NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security controls have no direct equivalent in 21 CFR Part 58 - Good Laboratory Practice (GLP). The highest concentration of gaps is in OT Supply Chain, Lifecycle, Physical with 1 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.
Which control domains have the most gaps between NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security and 21 CFR Part 58 - Good Laboratory Practice (GLP)?
The domain with the highest gap count is OT Supply Chain, Lifecycle, Physical (1 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.
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