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21 CFR Part 58 — Good Laboratory Practice (GLP)vsNIST SP 800-171A Rev 3 — Assessing CUI Security Requirements

See exactly how 21 CFR Part 58 — Good Laboratory Practice (GLP) controls map to NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements. Pre-computed mappings, identified gaps, and coverage analysis.

10
Controls Mapped
21
Gaps Found
13%
Coverage

According to the TheArtOfService Compliance Knowledge Graph:

21 CFR Part 58 — Good Laboratory Practice (GLP) maps to NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements with 13% coverage across 4 directly mapped controls. Analysis of 31 21 CFR Part 58 — Good Laboratory Practice (GLP) controls identifies 27 compliance gaps — primarily concentrated in Test Articles and Protocol (Subparts F & G).

Source: TheArtOfService Knowledge Graph | 31 controls analysed | 693 frameworks | 819K+ cross-framework mappings

Control Mappings

Showing 10 of 10 mapped controls across 2 domains. Sign up to explore all 819K+ mappings across 693 frameworks.

General Provisions (Subpart A)(6 mappings)

58.1Scope3 targets
→3.3Record Completion and Maintenance
→FEDRAMP-CM-6Configuration Settings
→FEDRAMP-CP-9System Backup
58.3Definitions3 targets
→3.3Record Completion and Maintenance
→FEDRAMP-CM-6Configuration Settings
→FEDRAMP-CP-9System Backup

Facilities (Subpart C)(4 mappings)

58.43Animal Care Facilities
→3.10Physical and Environmental Protection
58.49Laboratory Operation Areas3 targets
→3.1Food Safety and Quality Manual
→3.2Document Control
→3.4Internal Audits

Related Comparisons

Other 21 CFR Part 58 — Good Laboratory Practice (GLP) comparisons

21 CFR Part 58 — Good Laboratory Practice (GLP) vs NIS2 Directive Implementing Acts4 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs UK Telecommunications (Security) Act 20214 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs ISO/IEC 27011:20243 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs FedRAMP Rev 53 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs ISO/IEC 27400:20223 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs CFTC System Safeguards (17 CFR 37, 38, 39, 49)3 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs SSAE 18 SOC 1 — Report on Controls at a Service Organisation (ICFR)3 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs AWWA Cybersecurity Guidance for the Water Sector (American Water Works Association)3 mappings

Other NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements comparisons

UK Telecommunications (Security) Act 2021 vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsSouth Korea Cloud Security Assurance Program (CSAP) vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsPAS 1192-5:2015 — Security-Minded Approach to BIM and Digital Built Environments vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsCanada ITSG-33 — IT Security Risk Management vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsNew Zealand Information Security Manual (NZISM) vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsMARS-E — Minimum Acceptable Risk Standards for Exchanges vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsNRC 10 CFR 73.54 — Nuclear Facility Cybersecurity vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements21 mappingsTISAX — Trusted Information Security Assessment Exchange vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements20 mappings

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What are the key differences between 21 CFR Part 58 — Good Laboratory Practice (GLP) and NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements?

21 CFR Part 58 — Good Laboratory Practice (GLP) has 31 controls across its framework, while NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements covers 35 controls. Direct mapping analysis identifies 4 overlapping controls (13% coverage). The frameworks diverge most significantly in Test Articles and Protocol (Subparts F & G), where 5 21 CFR Part 58 — Good Laboratory Practice (GLP) controls have no direct NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements equivalent.

How many controls map between 21 CFR Part 58 — Good Laboratory Practice (GLP) and NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements?

Of 31 total 21 CFR Part 58 — Good Laboratory Practice (GLP) controls, 4 map directly to NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements controls — representing 13% coverage. The remaining 27 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.

What are the compliance gaps when mapping 21 CFR Part 58 — Good Laboratory Practice (GLP) to NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements?

27 21 CFR Part 58 — Good Laboratory Practice (GLP) controls have no direct equivalent in NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements. The highest concentration of gaps is in Test Articles and Protocol (Subparts F & G) with 5 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.

Which control domains have the most gaps between 21 CFR Part 58 — Good Laboratory Practice (GLP) and NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements?

The domain with the highest gap count is Test Articles and Protocol (Subparts F & G) (5 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.

Related Resources

How to Map Controls Across Frameworks|Multi-Framework Compliance Guide|Compliance Glossary

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