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Cross-Framework Mapping

NIST SP 800-171A Rev 3 - Assessing CUI Security Requirementsvs21 CFR Part 211 - Current Good Manufacturing Practice

See exactly how NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements controls map to 21 CFR Part 211 - Current Good Manufacturing Practice. Pre-computed mappings, identified gaps, and coverage analysis.

15
Controls Mapped
20
Gaps Found
26%
Coverage

According to the TheArtOfService Compliance Knowledge Graph:

NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements maps to 21 CFR Part 211 - Current Good Manufacturing Practice with 26% coverage across 9 directly mapped controls. Analysis of 35 NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements controls identifies 26 compliance gaps — primarily concentrated in System Protection and Communications.

Source: TheArtOfService Knowledge Graph | 35 controls analysed | 718 frameworks | 332K+ cross-framework mappings

Control Mappings

Showing 15 of 15 mapped controls across 5 domains. Sign up to explore all 332K+ mappings across 718 frameworks.

Access Control and Identification(3 mappings)

3.1Physical Security3 targets
→CFR211-C-48Section 211.48 - Plumbing
→CFR211-F-113Section 211.113 - Control of Microbiological Contamination
→CFR211-I-176Section 211.176 - Penicillin Contamination

Incident Response and Media Protection(3 mappings)

3.16System and Services Acquisition
→CFR211-J-184Section 211.184 - Component, Drug Product Container, Closure, and Labeling Records
3.17Supply Chain Risk Management
→CFR211-J-184Section 211.184 - Component, Drug Product Container, Closure, and Labeling Records
3.5Securely Dispose of Data
→CFR211-J-184Section 211.184 - Component, Drug Product Container, Closure, and Labeling Records

Awareness, Training, and Personnel(3 mappings)

3.2Establish and Maintain a Data Inventory3 targets
→CFR211-C-48Section 211.48 - Plumbing
→CFR211-F-113Section 211.113 - Control of Microbiological Contamination
→CFR211-I-176Section 211.176 - Penicillin Contamination

Audit, Assessment, and Monitoring(4 mappings)

3.3Configure Data Access Control Lists
→CFR211-A-3Section 211.3 - Definitions
3.4Enforce Data Retention3 targets
→CFR211-C-48Section 211.48 - Plumbing
→CFR211-F-113Section 211.113 - Control of Microbiological Contamination
→CFR211-I-176Section 211.176 - Penicillin Contamination

System Protection and Communications(2 mappings)

FEDRAMP-CM-6Configuration Settings
→CFR211-A-3Section 211.3 - Definitions
FEDRAMP-CP-9System Backup
→CFR211-A-3Section 211.3 - Definitions

Related Comparisons

Other NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements comparisons

NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs NIST SP 800-82 Revision 3: Guide to Industrial Control Systems (ICS) Security20 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs NIST SP 800-53 Rev 518 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs MTCS (Singapore)17 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs ISO 27001:202217 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs NIST Privacy Framework16 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs ISO 1348516 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs NIST SP 800-14615 mappingsNIST SP 800-171A Rev 3 - Assessing CUI Security Requirements vs NIST SP 800-14515 mappings

Other 21 CFR Part 211 - Current Good Manufacturing Practice comparisons

21 CFR Part 58 - Good Laboratory Practice (GLP) vs 21 CFR Part 211 - Current Good Manufacturing Practice16 mappingsFDA Quality Management System Regulation (QMSR) vs 21 CFR Part 211 - Current Good Manufacturing Practice8 mappingsPIC/S Guide to Good Manufacturing Practice for Medicinal Products vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappingsISO 15189:2022 - Medical Laboratories Requirements for Quality and Competence vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappingsAS9100D:2016 - Quality Management Systems for Aviation, Space, and Defence vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappingsBRCGS Global Standard for Food Safety Issue 9 vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappingsAS9100D - Aerospace Quality Management System vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappingsISO/IEC 27003:2017 vs 21 CFR Part 211 - Current Good Manufacturing Practice5 mappings

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What are the key differences between NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements and 21 CFR Part 211 - Current Good Manufacturing Practice?

NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements has 35 controls across its framework, while 21 CFR Part 211 - Current Good Manufacturing Practice covers 78 controls. Direct mapping analysis identifies 9 overlapping controls (26% coverage). The frameworks diverge most significantly in System Protection and Communications, where 13 NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements controls have no direct 21 CFR Part 211 - Current Good Manufacturing Practice equivalent.

How many controls map between NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements and 21 CFR Part 211 - Current Good Manufacturing Practice?

Of 35 total NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements controls, 9 map directly to 21 CFR Part 211 - Current Good Manufacturing Practice controls — representing 26% coverage. The remaining 26 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.

What are the compliance gaps when mapping NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements to 21 CFR Part 211 - Current Good Manufacturing Practice?

26 NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements controls have no direct equivalent in 21 CFR Part 211 - Current Good Manufacturing Practice. The highest concentration of gaps is in System Protection and Communications with 13 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.

Which control domains have the most gaps between NIST SP 800-171A Rev 3 - Assessing CUI Security Requirements and 21 CFR Part 211 - Current Good Manufacturing Practice?

The domain with the highest gap count is System Protection and Communications (13 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.

Related Resources

How to Map Controls Across Frameworks|Multi-Framework Compliance Guide|Compliance Glossary

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