Cross-Framework Mapping

EU Clinical Trials Regulation (CTR 536/2014)vsICH E6(R3) - Good Clinical Practice

See exactly how EU Clinical Trials Regulation (CTR 536/2014) controls map to ICH E6(R3) - Good Clinical Practice. Pre-computed mappings, identified gaps, and coverage analysis.

13
Controls Mapped
17
Gaps Found
27%
Coverage

According to the TheArtOfService Compliance Knowledge Graph:

EU Clinical Trials Regulation (CTR 536/2014) maps to ICH E6(R3) - Good Clinical Practice with 27% coverage across 8 directly mapped controls. Analysis of 30 EU Clinical Trials Regulation (CTR 536/2014) controls identifies 22 compliance gaps — primarily concentrated in CTR - Authorisation Procedure and Substantial Modifications (Ch II-III).

Source: TheArtOfService Knowledge Graph | 30 controls analysed | 718 frameworks | 332K+ cross-framework mappings

Control Mappings

Showing 13 of 13 mapped controls across 4 domains. Sign up to explore all 332K+ mappings across 718 frameworks.

CTR - Subject Protection and Informed Consent (Ch V)(2 mappings)

CTR-Art.28General rules on subject protection (Article 28)
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
CTR-Art.29Informed consent (Article 29)
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity

CTR - Start, End and Safety Reporting (Ch VI-VII)(4 mappings)

CTR-Art.41_42Adverse-event and SUSAR reporting (Articles 41-42)2 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-IRB-IEC-EthicsCommittee-InformedConsent-VulnerableICH E6 Section 3 - Institutional Review Board (IRB) + Independent Ethics Committee (IEC) + Informed Consent + Vulnerable Populations
CTR-Art.43Annual safety reporting (Article 43)2 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-IRB-IEC-EthicsCommittee-InformedConsent-VulnerableICH E6 Section 3 - Institutional Review Board (IRB) + Independent Ethics Committee (IEC) + Informed Consent + Vulnerable Populations

CTR - Conduct, Manufacturing and Labelling (Ch VIII-X)(6 mappings)

CTR-Art.47Compliance with the protocol and Good Clinical Practice (Article 47)2 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-IRB-IEC-EthicsCommittee-InformedConsent-VulnerableICH E6 Section 3 - Institutional Review Board (IRB) + Independent Ethics Committee (IEC) + Informed Consent + Vulnerable Populations
CTR-Art.48Monitoring (Article 48)2 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-IRB-IEC-EthicsCommittee-InformedConsent-VulnerableICH E6 Section 3 - Institutional Review Board (IRB) + Independent Ethics Committee (IEC) + Informed Consent + Vulnerable Populations
CTR-Art.57_58Clinical trial master file and archiving (Articles 57-58)2 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-Investigator-Qualifications-Resources-Communication-SafetyReportingICH E6 Section 4 - Investigator + Qualifications + Resources + Communication + Safety Reporting + Source Document Verification

CTR - CTIS, Cooperation and Final Provisions (Ch XIV-XIX)(1 mappings)

CTR-Art.80_81_82EU portal, EU database and functionality (Articles 80-82) - CTIS
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity

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What are the key differences between EU Clinical Trials Regulation (CTR 536/2014) and ICH E6(R3) - Good Clinical Practice?

EU Clinical Trials Regulation (CTR 536/2014) has 30 controls across its framework, while ICH E6(R3) - Good Clinical Practice covers 9 controls. Direct mapping analysis identifies 8 overlapping controls (27% coverage). The frameworks diverge most significantly in CTR - Authorisation Procedure and Substantial Modifications (Ch II-III), where 5 EU Clinical Trials Regulation (CTR 536/2014) controls have no direct ICH E6(R3) - Good Clinical Practice equivalent.

How many controls map between EU Clinical Trials Regulation (CTR 536/2014) and ICH E6(R3) - Good Clinical Practice?

Of 30 total EU Clinical Trials Regulation (CTR 536/2014) controls, 8 map directly to ICH E6(R3) - Good Clinical Practice controls — representing 27% coverage. The remaining 22 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.

What are the compliance gaps when mapping EU Clinical Trials Regulation (CTR 536/2014) to ICH E6(R3) - Good Clinical Practice?

22 EU Clinical Trials Regulation (CTR 536/2014) controls have no direct equivalent in ICH E6(R3) - Good Clinical Practice. The highest concentration of gaps is in CTR - Authorisation Procedure and Substantial Modifications (Ch II-III) with 5 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.

Which control domains have the most gaps between EU Clinical Trials Regulation (CTR 536/2014) and ICH E6(R3) - Good Clinical Practice?

The domain with the highest gap count is CTR - Authorisation Procedure and Substantial Modifications (Ch II-III) (5 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.

This platform provides educational compliance tools, not legal, regulatory, or professional compliance advice. Cross-framework mappings are AI-assisted interpretations and do not reproduce or replace official standards. Framework names and trademarks belong to their respective owners. Consult qualified professionals for your specific compliance requirements. See our Terms of Service.