Cross-Framework Mapping

COSO Internal Control - Integrated Framework (2013)vsICH E6(R3) - Good Clinical Practice

See exactly how COSO Internal Control - Integrated Framework (2013) controls map to ICH E6(R3) - Good Clinical Practice. Pre-computed mappings, identified gaps, and coverage analysis.

6
Controls Mapped
42
Gaps Found
4%
Coverage

According to the TheArtOfService Compliance Knowledge Graph:

COSO Internal Control - Integrated Framework (2013) maps to ICH E6(R3) - Good Clinical Practice with 4% coverage across 2 directly mapped controls. Analysis of 48 COSO Internal Control - Integrated Framework (2013) controls identifies 46 compliance gaps — primarily concentrated in Control Environment.

Source: TheArtOfService Knowledge Graph | 48 controls analysed | 718 frameworks | 330K+ cross-framework mappings

Control Mappings

Showing 6 of 6 mapped controls across 1 domains. Sign up to explore all 330K+ mappings across 718 frameworks.

Control Activities(6 mappings)

CA-10Selects and Develops Control Activities3 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-Annex2-DecentralisedClinicalTrials-DCT-eConsent-Remote-WearablesICH E6(R3) Annex 2 - Decentralised Clinical Trial (DCT) Elements + eConsent + Remote Monitoring + Wearables + Real-World Evidence
ICH-E6-EssentialDocs-TMF-eTMF-ArchiveRetention-ICH-Section8ICH E6 Section 8 - Essential Documents + Trial Master File (TMF) + eTMF + Archive + Retention
CA-12Deploys Through Policies and Procedures3 targets
ICH-E6-Annex1-ElectronicSystems-CSV-eSig-Audit-ALCOA-DataIntegrityICH E6(R3) Annex 1 - Computer Systems + Computer System Validation (CSV) + Electronic Signature + Audit Trail + ALCOA+ Data Integrity
ICH-E6-Annex2-DecentralisedClinicalTrials-DCT-eConsent-Remote-WearablesICH E6(R3) Annex 2 - Decentralised Clinical Trial (DCT) Elements + eConsent + Remote Monitoring + Wearables + Real-World Evidence
ICH-E6-EssentialDocs-TMF-eTMF-ArchiveRetention-ICH-Section8ICH E6 Section 8 - Essential Documents + Trial Master File (TMF) + eTMF + Archive + Retention

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What are the key differences between COSO Internal Control - Integrated Framework (2013) and ICH E6(R3) - Good Clinical Practice?

COSO Internal Control - Integrated Framework (2013) has 48 controls across its framework, while ICH E6(R3) - Good Clinical Practice covers 9 controls. Direct mapping analysis identifies 2 overlapping controls (4% coverage). The frameworks diverge most significantly in Control Environment, where 16 COSO Internal Control - Integrated Framework (2013) controls have no direct ICH E6(R3) - Good Clinical Practice equivalent.

How many controls map between COSO Internal Control - Integrated Framework (2013) and ICH E6(R3) - Good Clinical Practice?

Of 48 total COSO Internal Control - Integrated Framework (2013) controls, 2 map directly to ICH E6(R3) - Good Clinical Practice controls — representing 4% coverage. The remaining 46 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.

What are the compliance gaps when mapping COSO Internal Control - Integrated Framework (2013) to ICH E6(R3) - Good Clinical Practice?

46 COSO Internal Control - Integrated Framework (2013) controls have no direct equivalent in ICH E6(R3) - Good Clinical Practice. The highest concentration of gaps is in Control Environment with 16 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.

Which control domains have the most gaps between COSO Internal Control - Integrated Framework (2013) and ICH E6(R3) - Good Clinical Practice?

The domain with the highest gap count is Control Environment (16 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.

This platform provides educational compliance tools, not legal, regulatory, or professional compliance advice. Cross-framework mappings are AI-assisted interpretations and do not reproduce or replace official standards. Framework names and trademarks belong to their respective owners. Consult qualified professionals for your specific compliance requirements. See our Terms of Service.