TheArtOfService
Cross-Framework Mapping

21 CFR Part 58 — Good Laboratory Practice (GLP)vsCISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines

See exactly how 21 CFR Part 58 — Good Laboratory Practice (GLP) controls map to CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines. Pre-computed mappings, identified gaps, and coverage analysis.

5
Controls Mapped
26
Gaps Found
10%
Coverage

According to the TheArtOfService Compliance Knowledge Graph:

21 CFR Part 58 — Good Laboratory Practice (GLP) maps to CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines with 10% coverage across 3 directly mapped controls. Analysis of 31 21 CFR Part 58 — Good Laboratory Practice (GLP) controls identifies 28 compliance gaps — primarily concentrated in Test Articles and Protocol (Subparts F & G).

Source: TheArtOfService Knowledge Graph | 31 controls analysed | 693 frameworks | 819K+ cross-framework mappings

Control Mappings

Showing 5 of 5 mapped controls across 2 domains. Sign up to explore all 819K+ mappings across 693 frameworks.

General Provisions (Subpart A)(4 mappings)

58.1Scope2 targets
→FEDRAMP-AC-1Access Control Policy and Procedures
→FEDRAMP-AC-2Account Management
58.3Definitions2 targets
→FEDRAMP-AC-1Access Control Policy and Procedures
→FEDRAMP-AC-2Account Management

Facilities (Subpart C)(1 mappings)

58.43Animal Care Facilities
→ICS-AC-4Physical access controls

Related Comparisons

Other 21 CFR Part 58 — Good Laboratory Practice (GLP) comparisons

21 CFR Part 58 — Good Laboratory Practice (GLP) vs NIST SP 800-171A Rev 3 — Assessing CUI Security Requirements4 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs NIS2 Directive Implementing Acts4 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs UK Telecommunications (Security) Act 20214 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs ISO/IEC 27011:20243 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs FedRAMP Rev 53 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs ISO/IEC 27400:20223 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs CFTC System Safeguards (17 CFR 37, 38, 39, 49)3 mappings21 CFR Part 58 — Good Laboratory Practice (GLP) vs SSAE 18 SOC 1 — Report on Controls at a Service Organisation (ICFR)3 mappings

Other CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines comparisons

TISAX — Trusted Information Security Assessment Exchange vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines23 mappingsAWWA Cybersecurity Guidance for the Water Sector (American Water Works Association) vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines23 mappingsCSA CCM v4 vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines22 mappingsNIST SP 800-82 Rev 3 — Guide to OT Security vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines22 mappingsNIS2 Directive Implementing Acts vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines22 mappingsFAA Cybersecurity Framework for Aviation vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines22 mappingsASD Information Security Manual (ISM) vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines21 mappingsSouth Korea ISMS-P vs CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines21 mappings

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Popular framework comparisons

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What are the key differences between 21 CFR Part 58 — Good Laboratory Practice (GLP) and CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines?

21 CFR Part 58 — Good Laboratory Practice (GLP) has 31 controls across its framework, while CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines covers 42 controls. Direct mapping analysis identifies 3 overlapping controls (10% coverage). The frameworks diverge most significantly in Test Articles and Protocol (Subparts F & G), where 5 21 CFR Part 58 — Good Laboratory Practice (GLP) controls have no direct CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines equivalent.

How many controls map between 21 CFR Part 58 — Good Laboratory Practice (GLP) and CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines?

Of 31 total 21 CFR Part 58 — Good Laboratory Practice (GLP) controls, 3 map directly to CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines controls — representing 10% coverage. The remaining 28 controls represent compliance gaps requiring additional documentation or compensating controls to satisfy both frameworks simultaneously.

What are the compliance gaps when mapping 21 CFR Part 58 — Good Laboratory Practice (GLP) to CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines?

28 21 CFR Part 58 — Good Laboratory Practice (GLP) controls have no direct equivalent in CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines. The highest concentration of gaps is in Test Articles and Protocol (Subparts F & G) with 5 unmapped controls. These gaps represent areas where additional controls, policies, or documentation must be created to achieve compliance with both frameworks.

Which control domains have the most gaps between 21 CFR Part 58 — Good Laboratory Practice (GLP) and CISA ICS-CERT Advisories and Industrial Control Systems Security Guidelines?

The domain with the highest gap count is Test Articles and Protocol (Subparts F & G) (5 gaps). Export the full domain-by-domain gap breakdown via the Professional tier to generate a prioritised remediation roadmap.

Related Resources

How to Map Controls Across Frameworks|Multi-Framework Compliance Guide|Compliance Glossary

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