Before work with closed systems starts, operators' likely exposure to aerosols carrying GMOs must be risk assessed to decide whether respiratory protection has to be worn, and that document must be kept and given to the Regulator if asked for. The guideline notes that closed systems are expected to release aerosols only very rarely, but that this may be more likely at particular moments, such as sampling or opening valves, that an assessment is considered necessary where exposure could have serious consequences, that AS/NZS 1715 gives guidance on respiratory protection, and that C68 requires the records to be maintained.
The graph holds this control, the 0 it maps to, and the evidence behind each claim, over MCP and REST.