Trials should be scientifically valid for their purpose and rest on adequate, current knowledge: the nonclinical and clinical data available on the product should support the trial, the design should reflect what is known about the product, the condition, the underlying biology and the intended population, and current science should be reviewed periodically because new information during the trial may call for changes.
The graph holds this control, the 0 it maps to, and the evidence behind each claim, over MCP and REST.